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Gregory Petsko

My research is concerned with the three-dimensional structures of proteins and their biochemical functions. Most of my work is done in collaboration with Prof. Dagmar Ringe; we share facilities, students, and a number of projects.

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 Gregory Petsko Biography

My research is concerned with the three-dimensional structures of proteins and their biochemical functions. Most of my work is done in collaboration with Prof. Dagmar Ringe; we share facilities, students, and a number of projects. The tools used by our group are X-ray crystallography, molecular biology (especially site-directed mutagenesis), yeast genetics, organic synthesis, enzyme kinetics and molecular dynamics calculations. These methods are being applied to several general problems; the ones I am most involved with include: the structural basis for efficient enzymic catalysis of proton and hydride transfer; the role of the metal ions in bridged bimetalloenzyme active sites; direct visualization of proteins in action by time-resolved protein crystallography; the evolution of new enzyme activities from old ones; and the biology of the quiescent state in eukaryotic cells.

figure1In some of these projects, we are trying to understand the structural basis for the catalytic power of the enzymes triose phosphate isomerase, xylose isomerase, mandelate racemase, aminopeptidase, mutarotase and ketosteroid isomerase. For all of them, structural information is being used to guide site-directed mutagenesis of the active site residues and combined quantum mechanics/molecular mechanics simulations of the catalytic reaction.

Protein crystallography is normally a static tool and cannot be used to follow biological reactions in real time. We have been involved in the development of new diffraction techniques, including Laue diffraction, that are capable of recording entire protein crystal data sets in a millisecond. When combined with low-temperature techniques, such methods can be used to determine the structures of catalytic intermediates.

A new area of research in the laboratory is the use of yeast genetics and biochemical techniques to study the quiscent state of eukaryotic cells. We have recently shown that cells arrest their cell cycle in G1 and then exit to the G0 state when unfolded proteins accumulate in the cytoplasm. Accompanying these cell cycle changes is a global shutdown in ribosomal protein expression. This process is partly under control of the heat shock transcription factor HSF. Another project that uses yeast genetics and molecular biology is our attempt to design a new metabolic pathway that will allow yeast to grow on lactonitrile or lactamide as sole carbon sources. The enzymes in this new pathway are being engineered from enzymes of the mandelonitrile pathway in bacteria by a combination of structure-directed and random mutagenesis.

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Books
Gregory Petsko in Genome Biology: The first 10 years

Gregory Petsko in Genome Biology: The first 10 years

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  • HOW TO BOOK Gregory Petsko?

    Our booking agents have successfully helped clients around the world secure talent like Gregory Petsko for both live and virtual events for over 15 years. The team at All American Entertainment represents and listens to the needs of organizations and corporations seeking to hire keynote speakers, celebrities or entertainers for speaking engagements, personal appearances, product endorsements, or corporate entertainment. Fill out a booking request form for Gregory Petsko, or call our office at 1.800.698.2536 to discuss your upcoming event. One of our experienced agents will be happy to help you get pricing information and check availability for Gregory Petsko or any other celebrity of your choice.
  • HOW MUCH DOES IT COST TO BOOK Gregory Petsko?

    Booking fees for Gregory Petsko, or any other speakers and celebrities, are determined based on a number of factors and may change without notice. Pricing often varies between live and virtual events. Other factors that can affect speaker fees include the talent's schedule, market conditions, length of presentation, and the location of the event. The live and virtual event speaking fees listed on this website are intended to serve as a guideline only. In some cases, the actual quote may be above or below the stated range. For the most current fee to hire Gregory Petsko, please fill out the booking request form or call our office at 1.800.698.2536 to speak with an experienced booking agent.
  • WHO IS THE AGENT FOR Gregory Petsko?

    All American Entertainment has successfully secured celebrity talent like Gregory Petsko for clients worldwide for more than 15 years. As a full-service talent booking agency, we have access to virtually any speaker or celebrity in the world. Our agents are happy and able to submit an offer to the speaker or celebrity of your choice, letting you benefit from our reputation and long-standing relationships in the industry. Fill out the booking request form or call our office at 1.800.698.2536, and one of our agents will assist you to book Gregory Petsko for your next private or corporate function.
  • WHAT IS A FULL-SERVICE TALENT BOOKING AGENCY?

    All American Speakers is a "buyers agent" and exclusively represents talent buyers, meeting planners and event professionals, who are looking to secure celebrities and speakers for personal appearances, speaking engagements, corporate entertainment, public relations campaigns, commercials, or endorsements. We do not exclusively represent Gregory Petsko or claim ourselves as the exclusive booking agency, business manager, publicist, speakers bureau or management for Gregory Petsko or any other speaker or celebrity on this website. For more information on how we work and what makes us unique, please read the AAE Advantage.
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Gregory Petsko

My research is concerned with the three-dimensional structures of proteins and their biochemical functions. Most of my work is done in collaboration with Prof. Dagmar Ringe; we share facilities, students, and a number of projects.

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Massachusetts, USA
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Gregory Petsko Biography

My research is concerned with the three-dimensional structures of proteins and their biochemical functions. Most of my work is done in collaboration with Prof. Dagmar Ringe; we share facilities, students, and a number of projects. The tools used by our group are X-ray crystallography, molecular biology (especially site-directed mutagenesis), yeast genetics, organic synthesis, enzyme kinetics and molecular dynamics calculations. These methods are being applied to several general problems; the ones I am most involved with include: the structural basis for efficient enzymic catalysis of proton and hydride transfer; the role of the metal ions in bridged bimetalloenzyme active sites; direct visualization of proteins in action by time-resolved protein crystallography; the evolution of new enzyme activities from old ones; and the biology of the quiescent state in eukaryotic cells.

figure1In some of these projects, we are trying to understand the structural basis for the catalytic power of the enzymes triose phosphate isomerase, xylose isomerase, mandelate racemase, aminopeptidase, mutarotase and ketosteroid isomerase. For all of them, structural information is being used to guide site-directed mutagenesis of the active site residues and combined quantum mechanics/molecular mechanics simulations of the catalytic reaction.

Protein crystallography is normally a static tool and cannot be used to follow biological reactions in real time. We have been involved in the development of new diffraction techniques, including Laue diffraction, that are capable of recording entire protein crystal data sets in a millisecond. When combined with low-temperature techniques, such methods can be used to determine the structures of catalytic intermediates.

A new area of research in the laboratory is the use of yeast genetics and biochemical techniques to study the quiscent state of eukaryotic cells. We have recently shown that cells arrest their cell cycle in G1 and then exit to the G0 state when unfolded proteins accumulate in the cytoplasm. Accompanying these cell cycle changes is a global shutdown in ribosomal protein expression. This process is partly under control of the heat shock transcription factor HSF. Another project that uses yeast genetics and molecular biology is our attempt to design a new metabolic pathway that will allow yeast to grow on lactonitrile or lactamide as sole carbon sources. The enzymes in this new pathway are being engineered from enzymes of the mandelonitrile pathway in bacteria by a combination of structure-directed and random mutagenesis.

Gregory Petsko Videos

  • Gregory Petsko at TEDMED 2012
  • Greg Petsko: 15 Million in U.S. with Alzheimer's by 2050
  • Gregory Petsko (Brandeis/Weill Cornell Medical Center): The Post ...

Gregory Petsko Books

FAQs on booking Gregory Petsko

  • How to book Gregory Petsko?

    Our booking agents have successfully helped clients around the world secure talent like Gregory Petsko for both live and virtual events for over 15 years. The team at All American Entertainment represents and listens to the needs of organizations and corporations seeking to hire keynote speakers, celebrities or entertainers for speaking engagements, personal appearances, product endorsements, or corporate entertainment. Fill out a booking request form for Gregory Petsko, or call our office at 1.800.698.2536 to discuss your upcoming event. One of our experienced agents will be happy to help you get pricing information and check availability for Gregory Petsko or any other celebrity of your choice.
  • How much does it cost to book Gregory Petsko?

    Booking fees for Gregory Petsko, or any other speakers and celebrities, are determined based on a number of factors and may change without notice. Pricing often varies between live and virtual events. Other factors that can affect speaker fees include the talent's schedule, market conditions, length of presentation, and the location of the event. The live and virtual event speaking fees listed on this website are intended to serve as a guideline only. In some cases, the actual quote may be above or below the stated range. For the most current fee to hire Gregory Petsko, please fill out the booking request form or call our office at 1.800.698.2536 to speak with an experienced booking agent.
  • Who is the agent for Gregory Petsko?

    All American Entertainment has successfully secured celebrity talent like Gregory Petsko for clients worldwide for more than 15 years. As a full-service talent booking agency, we have access to virtually any speaker or celebrity in the world. Our agents are happy and able to submit an offer to the speaker or celebrity of your choice, letting you benefit from our reputation and long-standing relationships in the industry. Fill out the booking request form or call our office at 1.800.698.2536, and one of our agents will assist you to book Gregory Petsko for your next private or corporate function.
  • What is a full-service talent booking agency?

    All American Speakers is a "buyers agent" and exclusively represents talent buyers, meeting planners and event professionals, who are looking to secure celebrities and speakers for personal appearances, speaking engagements, corporate entertainment, public relations campaigns, commercials, or endorsements. We do not exclusively represent Gregory Petsko or claim ourselves as the exclusive booking agency, business manager, publicist, speakers bureau or management for Gregory Petsko or any other speaker or celebrity on this website. For more information on how we work and what makes us unique, please read the AAE Advantage.

Gregory Petsko is a keynote speaker and industry expert who speaks on a wide range of topics . The estimated speaking fee range to book Gregory Petsko for your event is available upon request. Gregory Petsko generally travels from MA, USA and can be booked for (private) corporate events, personal appearances, keynote speeches, or other performances. Similar motivational celebrity speakers are Jon Bergmann, David Houle, Read Montague, Bill Gates and E.O. Wilson. Contact All American Speakers for ratings, reviews, videos and information on scheduling Gregory Petsko for an upcoming live or virtual event.

Gregory Petsko Speaker Videos

  • Gregory Petsko at TEDMED 2012
    Greg Petsko: 15 Million in U.S. with Alzheimer's by 2050
  • Gregory Petsko (Brandeis/Weill Cornell Medical Center): The Post ...

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Speakers Similar to Gregory Petsko

This website is a resource for event professionals and strives to provide the most comprehensive catalog of thought leaders and industry experts to consider for speaking engagements. A listing or profile on this website does not imply an agency affiliation or endorsement by the talent.

All American Entertainment (AAE) exclusively represents the interests of talent buyers, and does not claim to be the agency or management for any speaker or artist on this site. AAE is a talent booking agency for paid events only. We do not handle requests for donation of time or media requests for interviews, and cannot provide celebrity contact information.

If you are the talent, and wish to request removal from this catalog or report an issue with your profile, please click here.

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