Patrick Casale

Patrick Casale is a TEDx speaker, keynote presenter, consultant, and thought leader whose work explores late-in-life Autism discovery, leadership, workplace culture, and the often-hidden cost of self-doubt.

Casale’s TEDx talk on discovering Autism in adulthood stands as a defining moment in his speaking career. Through deeply personal storytelling and clinical insight, he illuminated what it means to grow up undiagnosed, to learn how to mask in order to survive, and to later untangle identity, burnout, and belonging as an adult. His talk resonated widely for its honesty and clarity—giving language to experiences many people had lived but never heard named.

As a speaker, Casale brings a rare combination of lived experience, professional expertise, and executive-level leadership. He delivers keynotes and trainings for conferences, organizations, and leadership teams across the U.S. and internationally, helping audiences rethink neurodivergence, productivity, and performance through a more humane and inclusive lens. His work challenges systems that reward over-functioning and quiet suffering, while offering practical pathways toward psychological safety, sustainable leadership, and neurodivergent-affirming cultures.

Casale is the host of two globally recognized podcasts, All Things Private Practice and Divergent Conversations, where he has facilitated hundreds of conversations on Autism, ADHD, identity, leadership, entrepreneurship, and mental health. Across these platforms, he has become a trusted voice for professionals and leaders navigating late diagnosis, burnout, and the tension between success and self-abandonment.

He is also the author of an upcoming book focused on late-in-life Autism discovery, identity reconstruction, and the emotional aftermath of finally understanding your nervous system after decades of misattunement. The book extends the core themes of his TEDx talk—grief, relief, self-doubt, and self-trust—while offering readers language, validation, and hope.

Casale’s speaking style is authentic, disarming, and story-driven. He blends vulnerability, humor, and insight to create spaces where people feel seen without being pathologized. Whether addressing clinicians, executives, entrepreneurs, or organizational leaders, his message is consistent: self-doubt is not a flaw, neurodivergence is not a deficit, and leadership begins when we stop forcing people—including ourselves—to perform inside systems that were never built for us.