Born in Brighton, Griffiths was educated at Roedean School, Windlesham House School, Dorothy Stringer High School and Varndean College. She is a former member of the National Youth Music Theatre.
She first appeared on television in "Sea of Souls" and then "Sugar Rush," and on stage in "The White Devil."
In February 2006 it was announced she would be playing a "feisty", beautiful Marian in the BBC family drama series "Robin Hood," alongside Jonas Armstrong. Griffiths has said that her character "has been written as an intelligent, witty, biting character, and that's how I expected her to be."
Griffiths returned as Marian in the second series of "Robin Hood" in 2007, but her character was killed off in the final episode. Though this decision proved unpopular with fans of the series, it is said on a BBC Nottingham page that she left the show to pursue 'other opportunities'. It has been rumored that she wanted to leave the show to further her career in Hollywood. However, other sources say she was written out to allow the show to be taken in a new direction. She returned in the series finale a year later as a spectral vision of Marian.
In 2009 she made her West End debut in a revival of "Arcadia" and appeared in the ITV1 drama "Collision." On 5 September 2010, she appeared in the ITV drama "U Be Dead," playing Bethan Ancell and on 1 November 2010 she starred in ITV drama "The Little House."
In January 2011 Griffiths signed a talent holding deal with US television network CBS. It had been announced that she would play Jenna Lestrade, the lead in the CW zombie pilot "Awakening," however the show did not go ahead.
In November 2011 it was revealed that Griffiths would play Nora, the sister of vampire Eric Northman (Alexander Skarsgård), in the fifth season of HBO's "True Blood." During November 2011 Griffiths also appeared on stage at the Finborough Theatre, London, in the play "Atman" by Iain Finlay Macleod.
She voiced Mabel Dobbs in the Big Finish Productions Doctor Who audio drama The Auntie Matter, which was released in January 2013.
She has a diploma in mime from a world famous school in Paris and claims that Marcel Marceau was her greatest influence into the artistry of emotions and actions without words. She also admires performances of Judi Dench, Kate Winslet, and Jennifer Saunders.
Griffiths was originally cast in "Constantine" as the female lead Liv Aberdine, the daughter of a late friend, who comes to discover that she has the ability of seeing the supernatural world among us. She teams up with Constantine to fight the demons who have targeted her and learn more about her late father. Griffiths was dropped after Goyer and Cerone decided to take the series in a different creative direction. Instead the original comic character Zed will be written in. Angélica Celaya was later announced to fill the role. Some of Griffiths' final scenes from the pilot were re-shot, explaining why she doesn't join Constantine in his adventures as it was originally intended.
In April of 2015, Griffiths was cast in the upcoming AMC series "Preacher" as Emily Woodrow, a character described as a "no-nonsense" single mother, waitress, church organist, bookkeeper and the loyal right hand of Jesse Custer (Dominic Cooper).
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