Dr. Graham serves as Deputy Director of the NIAID Vaccine Research Center and assists the Director in establishing and focusing the scientific direction for the VRC as a premier intramural research organization. As Chief of the Viral Pathogenesis Laboratory, Dr. Graham also leads the development efforts for COVID-19 vaccines and universal influenza vaccines. In addition, he supports VRC product development through strategic advice on vaccine design as well as pre-clinical and clinical evaluation.
Dr. Graham is an immunologist, virologist, and clinical trials physician whose primary interests are viral pathogenesis, immunity, and vaccine development. His laboratory is focused on respiratory viral pathogens, pandemic preparedness, and emerging viral diseases. He applies structural biology, protein engineering, and other new technologies to create vaccines for unmet needs and emerging threats advancing the principles of precision vaccinology. He has been involved in the clinical evaluation of candidate vaccines for more than 30 years and has an ongoing interest in science education and expanding research opportunities for underrepresented minorities.
After graduating from Rice University in 1975, he obtained his MD from the University of Kansas School of Medicine in 1979. From 1979 to 1984 he served as intern, resident, and chief resident in internal medicine and from 1984 to 1986 was a clinical fellow in infectious diseases. He earned a PhD in microbiology and immunology at Vanderbilt University School of Medicine in 1991 and then rose to the rank of professor of medicine with a joint appointment in the department of microbiology and immunology. At Vanderbilt, Dr. Graham directed an R01-funded laboratory focused on RSV pathogenesis and was head of the Vanderbilt AIDS Vaccine Evaluation Unit, one of the original sites for the international clinical trials network funded by NIH designated for evaluating candidate HIV vaccines. In 2000, Dr. Graham was recruited as one of the founding investigators for the VRC.
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