She has starred in the television series Big Wolf on Campus and had recurring roles in What About Brian, Boston Legal, and Swingtown. She played the vampire Victoria Sutherland in the first two films of the Twilight saga, before being replaced by Bryce Dallas Howard due to scheduling conflicts. She starred in the ABC medical drama Off the Map, followed by the CBS series A Gifted Man and Under the Dome.

Lefevre was born and raised in Montreal, Quebec, to an English teacher father and a psychologist mother.Her father's family is originally from France and Northern Ireland, and her maternal grandparents are Jewish. Her stepfather is a rabbi.She has three sisters and speaks both English and French, though she grew up mostly speaking English.

Lefevre attended Centennial Academy, a private high school, and later studied creative arts at Dawson College.She studied theater for two summers at the Walnut Hill School in Natick, Massachusetts, and began a degree in education and literature at McGill University.

While working as a waitress at a sushi bar in Westmount, a regular customer, a Canadian television producer, overheard Lefevre telling the hostess that she wanted to be an actress.The producer got Lefevre her first audition, for a role in the sitcom Student Bodies. She didn't yet have a head shot, so submitted a Polaroid picture.

She didn't land the part but got a call back from the casting director, leading to a role in the Canadian TV series Big Wolf on Campus in 1999, playing Stacey Hanson.

Lefevre finished her degree at McGill, attending semesters between shoots.

Lefevre appeared in the film Confessions of a Dangerous Mind, directed by George Clooney, in 2002. She appeared in the television movies Picking Up and Dropping Off with Scott Wolf, and See Jane Date, and had a role in the romantic comedy Hatley High in 2003. In 2004, she played Etta Place in the Calgary-filmed TV movie The Legend of Butch and Sundance.

Lefevre moved to West Hollywood, California that year and appeared in the films Noel, directed by Chazz Palminteri and starring Penélope Cruz, and Head in the Clouds, also starring Cruz and Charlize Theron. In April 2004, Lefevre filmed the mystery-thriller The River King in Halifax, opposite Edward Burns.

Lefevre starred on the Fox sitcom Life on a Stick in 2005, playing Lily Ashton, a mall fast-food restaurant employee, and then appeared on the Fox series Pool Guys. She has guest starred on numerous other television series, including: Charmed, playing Olivia Callaway on the episode "Love's a Witch", playing Annie Isles on the fifth season of Undressed, and appearing on the short-lived ABC series What About Brian for eleven episodes.

Lefevre was cast as Annie Cartwright, the female lead in ABC's Life on Mars, a David E. Kelley remake of the original British TV series. She shot a pilot episode, but was replaced by Gretchen Mol when the series was revamped

Lefevre played the renegade vampire Victoria Sutherland in the film Twilight (2008), based on the novel of the same name by Stephenie Meyer. Lefevre wrote an impassioned letter to the director, explaining her desire to work with the filmmaker.

Lefevre described the essence of her character as "pure evil, pure instinct, pure malice, and very feline".

After reading that the author used the word "feline" to describe her character's agility, Lefevre watched lion attacks on YouTube to separate the movements of her character from those of normal people.

She also took trapeze classes in preparation for the wire work in the film.

Lefevre spent hours working on the costumes for her character, and described herself as "obsessed" with vampires after reading Bram Stoker's Dracula at the age of 14.

Lefevre was, at times, overwhelmed by the scrutiny she received from her involvement with Twilight. She participated in a promotional tour in November 2008, where she met and signed autographs for Twilight fans at Hot Topic stores in the U.S.

"It's the closest I will ever come in my life to being a rock star," she told The Canadian Press, describing an appearance on MuchMusic, where over 1,500 fans showed up in Toronto.

Over 2,500 fans showed up at a Wal-Mart in Salt Lake City, where Lefevre appeared to promote the DVD release of the film.

Overall though, Lefevre described herself as delighted by the attention and excitement of the fans.

She appeared in New Moon, the film's sequel, based on Meyer's second novel,which she completed shooting in Vancouver in May 2009.

Lefevre did not reprise her role of Victoria in Eclipse, the third film of the Twilight series, and was replaced by Bryce Dallas Howard. Summit Entertainment, the studio behind the films, attributed the change to scheduling conflicts; Eclipse and Barney's Version, an independent Canadian feature Lefevre had signed on to, both began filming on 17 August 2009.

Lefevre responded that she was "stunned" by the decision and "greatly saddened" not to continue her portrayal of Victoria, and never thought she would "lose the role over a 10 day overlap", in a statement to Access Hollywood.

The studio responded in a counter-statement, "The Twilight Saga: Eclipse is an ensemble production that has to accommodate the schedules of numerous actors while respecting the established creative vision of the filmmaker and most importantly the story."

Lefevre had appeared at the 2009 San Diego Comic-Con to promote New Moon the weekend before she was replaced.

Enthusiastic fans of the series reacted to the news of Lefevre's replacement with online petitions urging her return, and "Bring Back Rachelle" became a top-trending topic on Twitter in the afternoon of 29 July 2009.

Lefevre told Extra that she was "absolutely blown away" by support from fans, who also made her a tribute video on YouTube.

Lefevre did not attend the Los Angeles premiere of New Moon, tweeting that the event "was just 2 emotional 4 me & I couldn't manage it."

In 2009, Lefevre appeared in the CBC television miniseries The Summit, filmed in Ontario, and completed the film Bagman, starring Kevin Spacey.

In Bagman, she plays Emily Miller, a former press secretary for U.S. congressman Tom DeLay, who helped convict lobbyist Jack Abramoff (Kevin Spacey) in a political scandal involving Native American tribes.

Lefevre appeared in Barney's Version, a film adaptation of the award-winning Canadian novel by Mordecai Richler. Lefevre plays Clara, a manic depressive feminist poet who becomes the first wife of protagonist Barney Panofsky (Paul Giamatti). Her scenes were filmed in Rome in August 2009. The production continued on location in Montreal and New York.

Soon after the shoot, in November 2009, Lefevre shot the suspense film The Caller in Puerto Rico along with actors Lorna Raver and Stephen Moyer.

She replaced Brittany Murphy, who had exited the project.

Lefevre appeared in the pilot episode of the ABC television drama The Deep End on 21 January 2010.

She starred on the television drama Off the Map as Dr. Ryan Clark, a young doctor working in a South American medical clinic.

Developed by Grey's Anatomy-creator Shonda Rhimes, the series was filmed in Hawaii, debuted on 12 January 2011 and ran for 13 episodes before being canceled.

Lefevre was the voice of the 31st annual Genie Awards in March 2011, along with host William Shatner.

She was also cast in the NBC pilot, The Crossing, a drama set during the American Civil War. Lefevre plays Anna, a widow who begins an affair with a soldier.

In 2011, Lefevre joined the cast of the CBS TV drama, A Gifted Man, playing a doctor. The series starred Patrick Wilson and Jennifer Ehle.

Beginning in June 2013, Lefevre appeared in the 13-episode CBS summer thriller, Under the Dome, based on a 2009 best-selling novel of the same name by Stephen King. Lefevre joined an ensemble cast that includes Dean Norris, Mike Vogel, Colin Ford and Britt Robertson. The series is filmed in Wilmington, North Carolina

Lefevre lives in Los Angeles, California. As of June 2009, she was dating Jamie King, an actor who played Thomas Wyatt in the Showtime television series The Tudors.

In 2009, Lefevre donated $100 to Susan G. Komen for The Cure, a breast cancer charity, for every 10,000 people who followed her on Twitter. She also launched an eBay auction for the charity School On Wheels in August 2009, which provides tutoring to homeless children in Southern California.

Lefevre sold t-shirts and other merchandise signed by her fellow cast members from Twilight.

She is also an active supporter of Best Friends Animal Society, appearing in a public service announcement on behalf of the organization in November 2009, urging the public to adopt their next pet.

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