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Mark Roth

Cell Biologist, Fred Hutchinson Cancer Research Center

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 Mark Roth Biography

Our work in suspended animation derives from the fact that many animals exhibit what we call "metabolic flexibility," the ability to dial down their respiration and heartbeat and, in effect, "turn themselves off" in response to physical or environmental stress. Mammalian examples include hibernation - from ground squirrels to bears - as well as estivation (quiescence in response to heat) and embryonic diapause, a pause in embryonic development found in about 70 species of mammals. Meanwhile, many invertebrates can go dormant for days, months, and even years before reanimating. Finally, germ and somatic stem cells are well known to exit the cell cycle for extended periods of time and to re-enter only when it is favorable for the organism.

Our approach to understanding this flexibility has been to develop the means to stop animals for given periods of time and then reanimate them to normal function. We use the term suspended animation to refer to a state where all observable life processes (using high resolution light microscopy) are stopped: the animals do not move nor breathe and the heart does not beat. We have found that we are able to put a number of animals (yeast, nematodes, drosophila, frogs, and zebrafish) into a state of suspended animation for 24 hours or longer through one basic technique: reducing the concentration of oxygen.

By examining the precise oxygen tensions needed to induce suspended animation, we also found discrete and lethal oxygen tensions exist just above the oxygen level that enables suspended animation. In other words, there is a range of oxygen levels that is too low to support life, but going below that causes the animals to suspend. We hypothesized that perhaps we could prevent death in low oxygen situations by adding agents that effectively inhibit oxygen utilization and induce suspended animation.

Carbon monoxide, a well-known gas, is extremely toxic because it does exactly that: binds to sites where oxygen binds in the body. We found that we can successfully put nematodes into a state of suspended animation using carbon monoxide, and these results with invertebrate systems encouraged us to explore other systems and agents.

Using another highly toxic gas, hydrogen sulfide, we found we can reversibly reduce the metabolic rate of mice: exposed to 80 ppm of hydrogen sulfide, mice enter into what we call a "hibernation-like" state, where their core temperature can be reduced to as low as 11 degrees Celcius and their metabolic rate reduced by 10-fold as judged by carbon dioxide production and oxygen consumption. We've kept the animals in this state for 6 hours and they recover completely.

Our success in altering the metabolic rate of these mammals has given us the tools to pursue the possibility that exposure to hydrogen sulfide might reduce oxygen demand and improve outcome in animal models of human disease and injury. Consistent with this we have found that hydrogen sulfide exposure extends the survival limits of rodents exposed to otherwise lethal hypoxia and severe blood loss. Based on these and other findings from physician/scientists from around the world, a company I founded, Ikaria Inc., is engaged in phase II human trials to test the hypothesis that hydrogen sulfide improves outcome in critical care medicine.

In addition to working with mammals we have also been working with C. elegans where we can use genetics to further our understanding of the physiological response to hydrogen sulfide. We found that low-level exposure to hydrogen sulfide results in an adaptation in which metabolic rate is not changed but lifespan and thermotolerance are strikingly increased. By characterization of mutant lines that are sensitive or resistant to hydrogen sulfide we hope to establish a molecular mechanism to explain the activities of this hydrogen sulfide in biology and to further our understanding of metabolic flexibility in general.

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  • HOW TO BOOK Mark Roth?

    Our booking agents have successfully helped clients around the world secure talent like Mark Roth for both live and virtual events for over 15 years. The team at All American Entertainment represents and listens to the needs of organizations and corporations seeking to hire keynote speakers, celebrities or entertainers for speaking engagements, personal appearances, product endorsements, or corporate entertainment. Fill out a booking request form for Mark Roth, or call our office at 1.800.698.2536 to discuss your upcoming event. One of our experienced agents will be happy to help you get pricing information and check availability for Mark Roth or any other celebrity of your choice.
  • HOW MUCH DOES IT COST TO BOOK Mark Roth?

    Booking fees for Mark Roth, or any other speakers and celebrities, are determined based on a number of factors and may change without notice. Pricing often varies between live and virtual events. Other factors that can affect speaker fees include the talent's schedule, market conditions, length of presentation, and the location of the event. The live and virtual event speaking fees listed on this website are intended to serve as a guideline only. In some cases, the actual quote may be above or below the stated range. For the most current fee to hire Mark Roth, please fill out the booking request form or call our office at 1.800.698.2536 to speak with an experienced booking agent.
  • WHO IS THE AGENT FOR Mark Roth?

    All American Entertainment has successfully secured celebrity talent like Mark Roth for clients worldwide for more than 15 years. As a full-service talent booking agency, we have access to virtually any speaker or celebrity in the world. Our agents are happy and able to submit an offer to the speaker or celebrity of your choice, letting you benefit from our reputation and long-standing relationships in the industry. Fill out the booking request form or call our office at 1.800.698.2536, and one of our agents will assist you to book Mark Roth for your next private or corporate function.
  • WHAT IS A FULL-SERVICE TALENT BOOKING AGENCY?

    All American Speakers is a "buyers agent" and exclusively represents talent buyers, meeting planners and event professionals, who are looking to secure celebrities and speakers for personal appearances, speaking engagements, corporate entertainment, public relations campaigns, commercials, or endorsements. We do not exclusively represent Mark Roth or claim ourselves as the exclusive booking agency, business manager, publicist, speakers bureau or management for Mark Roth or any other speaker or celebrity on this website. For more information on how we work and what makes us unique, please read the AAE Advantage.
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Mark Roth

Cell Biologist, Fred Hutchinson Cancer Research Center

Travels From:
Seattle, WA, USA
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Virtual Event: Please Contact

Mark Roth Biography

Our work in suspended animation derives from the fact that many animals exhibit what we call "metabolic flexibility," the ability to dial down their respiration and heartbeat and, in effect, "turn themselves off" in response to physical or environmental stress. Mammalian examples include hibernation - from ground squirrels to bears - as well as estivation (quiescence in response to heat) and embryonic diapause, a pause in embryonic development found in about 70 species of mammals. Meanwhile, many invertebrates can go dormant for days, months, and even years before reanimating. Finally, germ and somatic stem cells are well known to exit the cell cycle for extended periods of time and to re-enter only when it is favorable for the organism.

Our approach to understanding this flexibility has been to develop the means to stop animals for given periods of time and then reanimate them to normal function. We use the term suspended animation to refer to a state where all observable life processes (using high resolution light microscopy) are stopped: the animals do not move nor breathe and the heart does not beat. We have found that we are able to put a number of animals (yeast, nematodes, drosophila, frogs, and zebrafish) into a state of suspended animation for 24 hours or longer through one basic technique: reducing the concentration of oxygen.

By examining the precise oxygen tensions needed to induce suspended animation, we also found discrete and lethal oxygen tensions exist just above the oxygen level that enables suspended animation. In other words, there is a range of oxygen levels that is too low to support life, but going below that causes the animals to suspend. We hypothesized that perhaps we could prevent death in low oxygen situations by adding agents that effectively inhibit oxygen utilization and induce suspended animation.

Carbon monoxide, a well-known gas, is extremely toxic because it does exactly that: binds to sites where oxygen binds in the body. We found that we can successfully put nematodes into a state of suspended animation using carbon monoxide, and these results with invertebrate systems encouraged us to explore other systems and agents.

Using another highly toxic gas, hydrogen sulfide, we found we can reversibly reduce the metabolic rate of mice: exposed to 80 ppm of hydrogen sulfide, mice enter into what we call a "hibernation-like" state, where their core temperature can be reduced to as low as 11 degrees Celcius and their metabolic rate reduced by 10-fold as judged by carbon dioxide production and oxygen consumption. We've kept the animals in this state for 6 hours and they recover completely.

Our success in altering the metabolic rate of these mammals has given us the tools to pursue the possibility that exposure to hydrogen sulfide might reduce oxygen demand and improve outcome in animal models of human disease and injury. Consistent with this we have found that hydrogen sulfide exposure extends the survival limits of rodents exposed to otherwise lethal hypoxia and severe blood loss. Based on these and other findings from physician/scientists from around the world, a company I founded, Ikaria Inc., is engaged in phase II human trials to test the hypothesis that hydrogen sulfide improves outcome in critical care medicine.

In addition to working with mammals we have also been working with C. elegans where we can use genetics to further our understanding of the physiological response to hydrogen sulfide. We found that low-level exposure to hydrogen sulfide results in an adaptation in which metabolic rate is not changed but lifespan and thermotolerance are strikingly increased. By characterization of mutant lines that are sensitive or resistant to hydrogen sulfide we hope to establish a molecular mechanism to explain the activities of this hydrogen sulfide in biology and to further our understanding of metabolic flexibility in general.

FAQs on booking Mark Roth

  • How to book Mark Roth?

    Our booking agents have successfully helped clients around the world secure talent like Mark Roth for both live and virtual events for over 15 years. The team at All American Entertainment represents and listens to the needs of organizations and corporations seeking to hire keynote speakers, celebrities or entertainers for speaking engagements, personal appearances, product endorsements, or corporate entertainment. Fill out a booking request form for Mark Roth, or call our office at 1.800.698.2536 to discuss your upcoming event. One of our experienced agents will be happy to help you get pricing information and check availability for Mark Roth or any other celebrity of your choice.
  • How much does it cost to book Mark Roth?

    Booking fees for Mark Roth, or any other speakers and celebrities, are determined based on a number of factors and may change without notice. Pricing often varies between live and virtual events. Other factors that can affect speaker fees include the talent's schedule, market conditions, length of presentation, and the location of the event. The live and virtual event speaking fees listed on this website are intended to serve as a guideline only. In some cases, the actual quote may be above or below the stated range. For the most current fee to hire Mark Roth, please fill out the booking request form or call our office at 1.800.698.2536 to speak with an experienced booking agent.
  • Who is the agent for Mark Roth?

    All American Entertainment has successfully secured celebrity talent like Mark Roth for clients worldwide for more than 15 years. As a full-service talent booking agency, we have access to virtually any speaker or celebrity in the world. Our agents are happy and able to submit an offer to the speaker or celebrity of your choice, letting you benefit from our reputation and long-standing relationships in the industry. Fill out the booking request form or call our office at 1.800.698.2536, and one of our agents will assist you to book Mark Roth for your next private or corporate function.
  • What is a full-service talent booking agency?

    All American Speakers is a "buyers agent" and exclusively represents talent buyers, meeting planners and event professionals, who are looking to secure celebrities and speakers for personal appearances, speaking engagements, corporate entertainment, public relations campaigns, commercials, or endorsements. We do not exclusively represent Mark Roth or claim ourselves as the exclusive booking agency, business manager, publicist, speakers bureau or management for Mark Roth or any other speaker or celebrity on this website. For more information on how we work and what makes us unique, please read the AAE Advantage.

Mark Roth is a keynote speaker and industry expert who speaks on a wide range of topics . The estimated speaking fee range to book Mark Roth for your event is available upon request. Mark Roth generally travels from Seattle, WA, USA and can be booked for (private) corporate events, personal appearances, keynote speeches, or other performances. Similar motivational celebrity speakers are Seth Berkley, Nathan Myhrvold, Harvey Fineberg, George Whitesides and Mary Roach. Contact All American Speakers for ratings, reviews, videos and information on scheduling Mark Roth for an upcoming live or virtual event.

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Speakers Similar to Mark Roth

This website is a resource for event professionals and strives to provide the most comprehensive catalog of thought leaders and industry experts to consider for speaking engagements. A listing or profile on this website does not imply an agency affiliation or endorsement by the talent.

All American Entertainment (AAE) exclusively represents the interests of talent buyers, and does not claim to be the agency or management for any speaker or artist on this site. AAE is a talent booking agency for paid events only. We do not handle requests for donation of time or media requests for interviews, and cannot provide celebrity contact information.

If you are the talent, and wish to request removal from this catalog or report an issue with your profile, please click here.

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