Gabriel Victora is an immunologist investigating acquired, or adaptive, immunity and clarifying the mechanisms by which organisms' responses to infection are improved. Victora has reconfigured and refined a number of molecular and cellular imaging methods in order to visualize, in real time, affinity maturation—the process through which adaptive immunity develops.
Through analysis of the proliferation, migration, and selection of B cells within the germinal centers of the lymphoid tissues, Victora has provided the most definitive evidence to date that affinity maturation of antibodies occurs in a manner akin to Darwinian evolution.
His research has practical implications for the development of new and more effective vaccines, whose protective immunity is based upon the workings of affinity maturation, and novel treatments for autoimmune disorders caused by aberrations in the germinal center reaction.
Victora received a B.M. (1998) and M.M. (2000) from the Mannes College of Music, an M.Sci. (2006) from the University of São Paulo, and a Ph.D. (2011) from New York University Medical School. From 2012 to 2016, he was a Whitehead Fellow at the Whitehead Institute for Biomedical Research at the Massachusetts Institute of Technology, and he is currently Laurie and Peter Grauer Assistant Professor and head of the Laboratory of Lymphocyte Dynamics at Rockefeller University. In 2017, Victora was named a MacArthur 'Genius Grant' Fellow.
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