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Sebastian Seung

Sebastian Seung is a leader in the new field of connectomics, currently the hottest space in neuroscience, which studies, in once-impossible detail, the wiring of the brain.

Categories: Technology
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In the brain, neurons are connected into a complex network. Sebastian Seung and his lab at MIT are inventing technologies for identifying and describing the connectome, the totality of connections between the brain's neurons -- think of it as the wiring diagram of the brain. We possess our entire genome at birth, but things like memories are not "stored" in the genome; they are acquired through life and accumulated in the brain. Seung's hypothesis is that "we are our connectome," that the connections among neurons is where memories and experiences get stored.

Seung and his collaborators, including Winfried Denk at the Max Planck Institute and Jeff Lichtman at Harvard University, are working on a plan to thin-slice a brain (probably starting with a mouse brain) and trace, from slice to slice, each neural pathway, exposing the wiring diagram of the brain and creating a powerful new way to visualize the workings of the mind. They're not the first to attempt something like this -- Sydney Brenner won a Nobel for mapping all the 7,000 connections in the nervous system of a tiny worm, C. elegans. But that took his team a dozen years, and the worm only had 302 nerve cells. One of Seung's breakthroughs is in using advanced imagining and AI to handle the crushing amount of data that a mouse brain will yield and turn it into richly visual maps that show the passageways of thought and sensation.


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  • Slate Magazine
    The Longform Guide to the Brain
    Slate Magazine
    Sebastian Seung, a professor of computational neuroscience at the Massachusetts Institute of Technology and a prominent proponent of the grand theory, describes the connectome as the place where 'nature meets nurture.' “Hayworth takes this theory a few ...
  • The Facts About Fiction, the Fiction About Facts
    Huffington Post
    (Currently the non-fiction book is Connectome: How the Brain's Wiring Makes Us Who We Are by Sebastian Seung, with The Great Convergence: Asia, The West, And the Logic of One World by Kishore Mahbubani waiting in the wings. And the fiction is Don ...

  • Ciência Hoje
    Investigadores criam jogo 'online' para mapearem neurónios - Ciência Hoje
    Ciência Hoje
    O jogo foi desenvolvido no laboratório do neurocientista Sebastian Seung, pois este não conseguiu criar um sistema de inteligência artificial que fizesse o trabalho sozinho. Seung quer utilizar o esquema do jogo para contribuir no mapeamento do ...
  • Jogo on-line ajuda cientistas a fazer mapa do cérebro
    Folha.com
    O jogo Eyewire (www.eyewire.org) foi desenvolvido pelo laboratório do neurocientista Sebastian Seung, do MIT (Instituto de Tecnologia de Massachusetts). Ao se ver incapaz de criar um sistema de inteligência artificial que desse conta de fazer o ...
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Connectome: How The Brain's Wiring Makes Us Who We Are
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